Plenary II: Allograft Microvascular Inflammation beyond HLA-DSA: Deciphering the different immunological mechanisms driving injury and outcome

Speaker(s)

• 

  Maarten Naesens, MD PhD

  Professor
  KU Leuven
  Leuven, Belgium
• 

  Alexandre Loupy, MD, PhD

  Professor of Nephrology and Epidemiology
  INSERM & Université Paris Cité, Paris Transplant Group
  NEUILLY-SUR-SEINE, Ile-de-France, France
• 

  Kieran Halloran, MD, MSc

  Associate professor
  University of Alberta
  Edmonton, AB, Canada

Moderator(s)

• 

  Anat Tambur, DMD PhD D(ABHI)

  HLA laboratory co-director
  Northwestern University
  Chicgao, IL
• 

  Nicole Valenzuela, PhD, F(ACHI)

  HLA Laboratory Director
  NorDx / MaineHealth
  Scarborough, ME

Allograft microvascular inflammation (MVI) is a hallmark histological feature of antibody-mediated allograft injury. However, microvascular inflammation most frequently occurs in the absence of detectable donor-specific anti-HLA antibodies. This highlights the need for a better understanding of the different phenotypes of MVI and the underlying mechanisms of allograft injury. This session will explore the different clinical presentations and outcomes of the Banff phenotypes of MVI and will discuss the role of the adaptive and innate immune responses in MVI beyond HLA-DSA.

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Allograft microvascular inflammation (MVI) is a hallmark histological feature of antibody-mediated allograft injury. However, microvascular inflammation most frequently occurs in the absence of detectable donor-specific anti-HLA antibodies. This highlights the need for a better understanding of the different phenotypes of MVI and the underlying mechanisms of allograft injury. This session will explore the different clinical presentations and outcomes of the Banff phenotypes of MVI and will discuss the role of the adaptive and innate immune responses in MVI beyond HLA-DSA.

Presentations:

• 10:30 AM - 11:00 AM US EDT

  Microvascular Inflammation after Kidney Transplantation – the story of a serial killer
  

  Speaker: Maarten Naesens, MD PhD – KU Leuven
• 11:00 AM - 11:30 AM US EDT

  MVI in Heart Transplant
  

  Speaker: Alexandre Loupy, MD, PhD – INSERM & Université Paris Cité, Paris Transplant Group
• 11:30 AM - 12:00 PM US EDT

  Rejection and Injury in the Lung Allograft
  

  Speaker: Kieran Halloran, MD, MSc – University of Alberta