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Xiaoxiao Wan, MD, PhD

Assistant Professor
Washington University School of Medicine
St louis, MO

Dr. Xiaoxiao Wan is an Assistant Professor in the Division of Immunobiology, Department of Pathology and Immunology at Washington University School of Medicine in St. Louis. His research focuses on investigating the pathogenesis and treatment of autoimmune diseases, with an emphasis on type 1 diabetes (T1D) and Sjögren's syndrome (SjD). Using animal models, they aim to identify disease-relevant epitopes recognized by pathogenic CD4⁺ and CD8⁺ T cells. For epitope discovery, they employ immunopeptidomics coupled with functional validation using antigen presentation assays. This pipeline can also be applied to human samples, enabling the identification of canonical and non-canonical epitopes relevant to human T1D and SjD and examination of human antigen-specific T cells. As an immunology lab, they also investigate how innate immune cells—such as tissue-resident macrophages and dendritic cells—instruct antigen-specific T cells to become pathogenic. This approach allows us to link the unique properties of the tissue microenvironment to autoimmune pathogenesis. Dr. Wan's areas of expertise include antigen processing and presentation, macrophage and dendritic cell biology, and the mechanisms of CD4⁺ and CD8⁺ T cell pathogenicity and tolerance during autoimmune responses in T1D and SjD.

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