Workshop 6: HLA Serotypes from Theory to Practice: Implementation in the HLA laboratory and impact in transplantation

Thursday, October 9, 2025

2:45 PM - 4:15 PM US EDT

Location: Grand Cypress D - F

CE: .23 CEC / 1.5 CME

Speaker(s)

Marcelo Fernandez-Vina, PhD, F (ACHI)

Professor
Department of Pathology Stanford University School of Medicine
Stanford, CA
Kazutoyo Osoegawa, PhD

Research Science & Technical Lead
Stanford Blood Center
Palo Alto, California
William Lane, MD, PhD, A(ACHI)

Director Tissue Typing Laboratory
Brigham and Women's Hospital
Boston, Massachusetts
Cathi Murphey, PhD, HCLD/CC(ABB), A(ACHI)

Director
SWID
Fair Oaks Ranch, Texas
Alberto Cardoso Martins Lima, PhD

Clinical Consulting Scientist
IGEN/AFIP and Federal University of Parana
Curitiba, Parana, Brazil

Panelist(s)

Renato De Marco, MSc (he/him/his)

co-director
Instituto Imunogenética, IGEN/AFIP
São Paulo, Sao Paulo, Brazil

Moderator(s)

Maria Bettinotti, PhD

Director, Immunogenetics Laboratory
Johns Hopkins University
Baltimore, MD
Arianne Mankey, CHS (ACHI)

HLA Clinical Lab Operations Manager
Stanford Blood Center Histocompatibility and Immunogenetics Laboratory
Palo Alto, CA

A new strategy for systematically classifying HLA alleles into associated antigens was recently approved by the W.H.O. Nomenclature Committee for Factors of the HLA System. The use of HLA Serotypes will facilitate virtual crossmatches and donor specific antibody assessments by offering a formal definition of antigens and informing the implementation of single antigen bead panels that encompass all clinically relevant variants.

To learn more please click here.

Learning Objectives:

Learn the approach to determine HLA serotypes utilizing an in-silico program – HLA to Allele Serotype (HATS).
Learn how to apply HLA serotypes in the clinical laboratory.
Educate the audience on the application of HLA serotypes at the regulatory level to include IMGT database and the OPTN histocompatibility equivalency tables.

Presentations:

2:45 PM - 2:57 PM US EDT

Serotypes: From concept to implementation
Speaker: Marcelo A. Fernandez-Vina, PhD, F (ACHI) – Department of Pathology Stanford University School of Medicine
2:57 PM - 3:09 AM US EDT

Bioinformatics for the assignment and validation of new Serotypes: Maintaining and updating the Serotype Database
Speaker: Kazutoyo Osoegawa, PhD – Stanford Blood Center
3:09 PM - 3:21 PM US EDT

Integrating the new Serotype Nomenclature into the Laboratory Workflow: A bioinformatic tool
Speaker: William Lane, MD, PhD, A(ACHI) – Brigham and Women's Hospital
3:21 PM - 3:34 PM US EDT

Using Serotypes for HLA Antibody Assessment in Solid Organ and Hematopoietic Cell Transplantation
Speaker: Cathi Murphey, PhD, HCLD/CC(ABB), A(ACHI) – SWID
3:34 PM - 3:46 PM US EDT

New Bioinformatic Tools for HLA Antibody Analysis and Serotype Assignment
Speaker: Alberto Cardoso Martins Lima, PhD – IGEN/AFIP and Federal University of Parana