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Opening Session: Molecular HLA Mismatch Analysis: 'Friend and Foe'

Monday, October 6, 2025
6:00 PM - 7:00 PM US EDT
Location: Grand Cypress D - F
CE: .15 CEC / 1 CME

The advancement of molecular HLA typing technologies, along with computational methods for analyzing B-cell and T-cell HLA determinants/targets (often referred to as "epitopes"), has led to the development of tools for assessing the degree of donor-recipient HLA disparity at the molecular level. This session will provide a historical overview of molecular HLA mismatch analysis, explore the various available tools, address their limitations, and critically evaluate the current clinical evidence regarding the use of these tools in transplant practices.

To learn more please click here.

Learning Objectives:

  1. Gain insights into the different concepts and available tools for performing molecular HLA mismatch analysis.
  2. Recognize how the application of these tools in clinical practices can be both potentially beneficial ("friend") and potentially detrimental ("foe") due to their limitations.
  3. Evaluate the current clinical evidence related to the use of these tools in transplantation practices.
The advancement of molecular HLA typing technologies, along with computational methods for analyzing B-cell and T-cell HLA determinants/targets (often referred to as "epitopes"), has led to the development of tools for assessing the degree of donor-recipient HLA disparity at the molecular level. This session will provide a historical overview of molecular HLA mismatch analysis, explore the various available tools, address their limitations, and critically evaluate the current clinical evidence regarding the use of these tools in transplant practices.

To learn more please click here.

Presentations:

  • 6:00 PM - 6:20 PM US EDT
    Introduction and History of the Molecular HLA Mismatch Analysis: Triplets, eplets, and their role in stem cell transplant

    Speaker: Medhat Askar, MD, PhD – Qatar University

  • 6:20 PM - 6:40 PM US EDT
    Eplets/EMS3D Score in Solid Organ Transplant

    Speaker: Aleksandar Senev, MD, PhD, F(EBTI), F(ACHI) – Northwestern University

  • 6:40 PM - 7:00 PM US EDT
    EMMA/snowflake/PIRCHE-II/Snow in Solid Organ Transplant

    Speaker: Sebastiaan Heidt, PhD – Erasmus MC