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Workshop 5: The Bioinformatics of Running an HLA Lab – It’s not for the faint of heart

Wednesday, October 8, 2025
2:45 PM - 4:15 PM US EDT
Location: Grand Cypress D - F
CE: .23 CEC / 1.5 CME

In this workshop, attendees will learn about and experiment with some of the lab tools that were created to enable the efficient handling of primary HLA laboratory data and multiple caveats of HLA matching for transplant. Through some carefully crafted examples and case studies, you will learn about some common pitfalls to avoid that could have potential clinical impacts and some established collaborations that will result in more tools to benefit HLA laboratory practices. Lastly, attendees of this workshop will get an overview of how ASHI proficiency Testing (PT) data are processed and some areas of improvement.

**Please prepare for this session by completing the following steps: click here

To learn more please click here.

Learning Objectives:

  1. Review some challenging HLA donor/recipient matching cases and different approaches for handling them.
  2. Learn about the ASHI PT pipeline and some current challenges.
  3. Develop a hands-on experience with primary data and some of the tools developed for better handling these data in a laboratory setting.
In this workshop, attendees will learn about and experiment with some of the lab tools that were created to enable the efficient handling of primary HLA laboratory data and multiple caveats of HLA matching for transplant. Through some carefully crafted examples and case studies, you will learn about some common pitfalls to avoid that could have potential clinical impacts and some established collaborations that will result in more tools to benefit HLA laboratory practices. Lastly, attendees of this workshop will get an overview of how ASHI proficiency Testing (PT) data are processed and some areas of improvement.

**Please prepare for this session by completing the following steps: click here

To learn more please click here.

Presentations:

  • 2:45 PM - 3:15 PM US EDT
    Calculating HLA Mismatches: Measuring the accuracy of a foundational histocompatibility interpretation

    Speaker: Nicholas K. Brown, PhD, F(ACHI) – University of Pennsylvania

  • 3:15 PM - 3:45 PM US EDT
    Handling PT Data, the Good, the Bad and the Ugly

    Speaker: Reut Hod Dvorai, PhD F(ACHI) – SUNY Upstate Medical University

  • 3:45 PM - 4:15 PM US EDT
    Getting your Feet Wet with Accessing your Lab’s HLA Data – a hands-on tutorial

    Speaker: Nicholas K. Brown, PhD, F(ACHI) – University of Pennsylvania